Two late goals for Wycombe saw Southend let a 3-1 lead slip to lose 4-3 at Adams Park and remain without a point this season.
Blues had gotten off to the perfect start in beautiful sunshine when Brandon Goodship’s first-time strike beat Ryan Allsop for the striker’s first goal in a Southend shirt.
Stephen Humphrys then doubled Blues’ lead in superb fashion, arching a brilliant strike from over 20-yards past the despairing dive of Allsop to make it 2-0.
That lead would be halved before the break when Mark Milligan put into his own net but Southend’s two-goal lead would be restored when Humphrys scored again straight after the restart.
Scott Kashket ensured a nervy finish by scoring with over half-an-hour to go while Southend’s goal frame was struck three times as Wycombe aimed to salvage their unbeaten league start.
And the Chairboys would grab a late equaliser as Wycombe flooded forward and defender Anthony Stewart scored in the 89th minute with it looking like the points would be shared.
But the comeback was completed in the second minute of stoppage time as Kashket ducked one way and then another before curling the ball beyond Bishop to win it for the Chairboys.
After letting a two-goal lead slip twice, it was a bitter pill to swallow for Southend who had looked deserving of at least a point on their travels but their wait to get off the mark goes on.