Kevin Maher's side kick off their Central League campaign at Peterborough UnitedSouthend United Under-21 side will start their Central League season on Tuesday 13 September with an away trip to Peterborough United (2pm Kick off)
The team, managed by Kevin Maher, will be hoping to build on last season's success where they finished 2015/16 by winning the Final Third South Development League Cup.
Many players in that side have now started to make strides in the First Team set up such as Jack Bridge, Jason Williams, Jordan Williams, Harry Kyrprianou and Dan Matsuzaka.
After a busy pre-season schedule, the first competitive fixture the U21s played this season was a narrow 2-1 defeat to Portsmouth in the Premier League Cup on Monday 22 August.
Stay tuned on Southend United's media channels for updates with match reaction online from Wednesday.