Pigott begins return on the bench, Weston partners Mooney up front for the Blues.
Southend United manager has named a strong squad for the game at Fleetwood Town's Highbury Stadium for the opening game of the League 1 season.
Brown has picked Myles Weston to partner David Mooney up front for the Blues, with Will Atkinson, Ryan Leonard, Anthony Wordsworth and Kevan Hurst making up the midfield.
The back five is the same back five that played in the League 2 play-off Final against Wycombe Wanderers – the last competitive game.
Blues: Bentley; White (c), Bolger, Barrett, Coker; Atkinson, Hurst, Leonard; Wordsworth; Weston; Mooney
Substitutes: T. Smith, Prosser, Worrall, Timlin, Payne, Hunt, Pigott.