The odds ahead of the home clash against the Stags at Roots Hall.
Southend have been priced up as the odds-on favourites at 8/13 by Sky Bet for three points at home to Mansfield on Good Friday.
The Blues sit comfortably inside the play-off places but time is running out to mount a charge for automatic promotion.
Mansfield have a seven-point gap to the relegation zone and are 5/1 to boost their survival bid with three points on the road.
The draw has been made a 13/5 shot. Southend have only won one of their last five matches and the Stags have the same recent record.
Southend striker Barry Corr is the 4/1 favourite in the first goalscorer betting and the top Mansfield contender is Vadaine Oliver at 8/1.
Top Tip: Barry Corr and Vadaine Oliver both to score at 15/2