The odds ahead of the Blues' trip to Devon in Sky Bet League Two.
Exeter and Southend both need three points to keep their respective hopes of a play-off place and automatic promotion alive.
The Grecians sit four points outside the top-seven with three matches left to play and Southend are five points behind third-placed Wycombe but do have a game in hand.
The Blues are 6/4 favourites with Sky Bet for three points on the road, hosts Exeter are on offer at 9/5 and the draw is a 23/10 chance.
Exeter forward Tom Nichols and Southend striker Barry Corr can’t be split as 5/1 favourites in the first goalscorer betting.
You can back both players to net in the encounter at 11/2.
Top Tip: Tom Nichols and Barry Corr both to score at 11/2