Two first half goals for Luton Town made it defeat for the second successive Sky Bet League Two game for Southend United.
Goals from Alex Lawless and Mark Cullen sealed a comfortable victory for the Hatters against an unlucky Blues side.
Blues boss Phil Brown makes two changes to the starting XI against Morecambe last week with Jack Payne and Luke Prosser missing out, the duo replaced by Will Atkinson and Cian Bolger.
There's positive news with the fact that Michael Timlin and Ryan Leonard have taken their place on the bench following spells on the sidelines with injuries.
It took a while for the game to really find a tempo and the closest both sides came to opening the scoring in the opening ten minutes were long range efforts from Conor Clifford and Atkinson.
Luton took the lead in the 16th minute through Lawless. After being put through by Jonathan Smith, Lawless curled the ball superbly past Dan Bentley and into the top corner to break the deadlock at Kenilworth Road.
Blues worked a neat free-kick involving Hurst and Clifford, with the latter firing narrowly past the post before Luton added their second goal of the game just after the half hour mark.
Bolger attempted to pass the ball to Clifford but after Andy Drury cut the ball out, his pass to Cullen in the box was fired home by the Luton striker, giving Bentley no chance.
Bolger's game was over just before the break as he never recovered from the earlier head injury and he was replaced by Leonard – who moved to right back, with skipper John White partnering Adam Thompson at the heart of the Southend United defence.
Brown played all his cards when he made a half-time double change – Jack Payne and Barry Corr replacing Atkinson and Shaq Coulthirst.
After the break, Blues came out with more vigour and purpose, with Hurst immediately seeing his cross just fly past the on-rushing Payne.
Payne was involved moments later but after a good run, he dragged his shot wide of Tyler's left-hand post.
Chances were falling to Blues and prior to Leonard firing wide of the goal, Blues had a good shout for a penalty after Thompson was taken down in the box but the referee waved away the protests.
Luton had chances themselves and just after the hour mark, Steve McNulty saw his header go just over Bentley's upright.
In the final 15 minutes, Blues attacking presence died down, and after Dave Penney was sent to the stands, Lawless had a chance to add a third goal but fired well over Bentley's crossbar.
As the minutes ticked by, Weston fired into the 1,033 Blues fans behind the goal after a Corr knock down to his strike partner.
However, that was to be that for Blues with the Bedfordshire side probably deserving their victory.
Blues: Bentley; White (c), Bolger (Leonard, 41), Thompson, Williams; Deegan, Clifford, Atkinson (Payne, 46); Weston, Coulthirst (Corr, 46), Hurst
Unused: Worrall, Timlin, Barnard, P. Smith