Ten-man Blues defeated in Buckinghamshire against the table-toppers.
It was to prove a disappointing afternoon for Blues at a chilly Adams Park, suffering a 4-1 defeat against table-toppers Wycombe Wanderers – despite taking an early lead through Jack Payne.
Payne pounced after just two minutes to put Blues ahead, but Wycombe battled back and ended up emphatically beating Blues – who finished the game with ten men after Jerome Williams was sent off.
Blues boss Phil Brown made two changes to the side that earned a 2-0 win over Northampton Town last time out in Sky Bet League Two. Brown had to make defensive alterations to his starting XI, with John White and Adam Thompson missing out through injury and suspension.
White – who instead took a place on the bench - hadn't trained for eight days through illness, whilst Thompson picked up his fifth yellow card in the game against the Cobblers.
It was a great start for the Blues, as Payne bagged from inside the box after a terrific run from Myles Weston. The winger broke the offside trap down the right hand side and his low cross was tucked in by Payne after just two minutes.
At the other end, Peter Murphy saw a snapshot cannon off the crossbar after Matt McClure's strike was blocked excellently by Luke Prosser.
However, just after the half an hour mark, winger Paris Cowan-Hall found an equaliser for Wycombe. The wideman got on the end of an Aaron Pierre knockdown to fire past Dan Bentley from inside the box.
On the stroke of half time, Wycombe took the lead. A hard cross from the left-hand side by Sammy Wood went through a number of bodies before finding McClure, who tapped home from two yards, as the Blues went in at the break 2-1 down.
Brown made a double change at half time, with Kevan Hurst and Gary Deegan replacing O'Toole and Weston.
And the change almost paid dividends moments after the break when Hurst's free kick almost caught out Matt Ingram in the Wanderers' goal.
Ten minutes after the break and David Worrall's dipping free kick flew over the bar, as Blues started the second 45 strongly.
And Worrall – who was named League Two's Player of the Month for his performances in November – went close again just moments later, with Ingram down smartly to stop a low strike from the Southend winger.
On the hour mark, Blues task was made harder. The returning Williams was shown a straight red card for a late challenge on Wycombe midfielder Josh Scowen.
With 25 minutes remaining, Bentley had to be out smartly to deny McClure, after Scowen slid the frontman in on goal.
A minute later, and Wycombe grabbed their third goal of the afternoon. Joe Jacobson showed great technique to bend his free kick around the wall and into the top corner of the net, despite Bentley getting a hand on the powerfully struck effort.
Against the ten men, Wycombe were creating more, and after Cowan-Hall fired wide, Gareth Ainsworth's side got a fourth goal, as McClure scored his second of the game, smashing home a great strike from the edge of the box with just over 20 minutes of the match remaining.
On 81 minutes, Blues were lucky to not concede again, as substitute Fred Onyedinma somehow skewed wide after White's clearance.
However, that was that, as Blues four-game winning streak came to an end at Adams Park.
Blues: Bentley; Leonard, Bolger, Prosser, Williams; Worrall, O'Toole (Deegan, 46), Timlin, Weston (Hurst, 46); Payne; Corr
Unused: P. Smith, White, Atkinson, Clifford, Coulthirst