Manager Paul Sturrock hopes to break an unwanted run of results against Morecambe on Saturday.
The two clubs have only ever met on four occasions in their history, with Southend yet to beat the Shrimps.
Those clashes have resulted in three wins for Morecambe and a draw, all of which Sturrock has presided over.
And the Scot is keen to end that wretched run at the Globe Arena on Saturday.
“Three defeats and one draw is our record against Morecambe since I have been here,” Sturrock told the official website.
“That’s our all time record as we have only played them four times as a club.
“They have a bit of an Indian sign on us so we have to rub that out on Saturday.
“But they are a big strong side who are in form and try and penetrate you all over the pitch.
“I don’t like that kind of record but they are there to be broken so lets see if we can get the result.”
Blues will be boosted by the return of defender Mark Phillips and midfielder John Spicer for the trip.
Phillips is available again following a groin problem, whilst Spicer has now completed his three-match suspension.
However, Luke Prosser is still out injured with a glute injury whilst Barry Corr (groin) and Neil Harris (knee) are also unavailable.
But despite the options now available to Sturrock, he is unsure if he will alter the side that beat Rotherham United 3-0 last weekend.
“There is always something in the back of my mind that you select horses for courses,” he said.
“I did that with Woodyard the game before as although he had a competent performance, I felt there was something needed for the Rotherham match. Thankfully it worked on that occasion.
“I have changed the team and lost and kept the same team and lost as well so there are no hard and fast rules.”
Meanwhile, Sturrock confirmed that the midfield target he has been tracking has suffered an injury.
Sturrock had hoped to complete a deal with an unnamed player this week but after a slight injury problem the 54-year-old will now wait until after the weekend before bringing in his target.
“We have been in negotiations with several clubs about central midfield players,” he admitted.
“One of the players has a knock at the moment, which hasn’t enabled him to come yet.
“I have been thinking about leaving it until he is ready as it is only suppose to be four or five days out. I decided Wednesday night I would wait for him.”