Striker Freddy Eastwood has been handed his first start in three weeks against York City today.
The Blues forward will partner Britt Assombalonga in attack against the Ministermen this afternoon.
Anthony Straker meanwhile replaces Mark Phillips in defence, who is on the bench, with Chris Barker moving to centre-back.
New signing Marc Laird is handed his debut in the middle of the park and Alex Woodyard will partner him.
Striker Barry Corr makes the bench following a groin injury.
Southend: Smith, Clohessy, Straker, Cresswell, Eastwood, Hurst, Assombalonga, Tomlin, Barker, Laird, Woodyard.
Subs: Corr, Martin, Clarke-Harris, Phillips, Bentley, Spicer, Benyon.